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D-A-HYDROXYGLUTARIC ACID DISODIUM
eCollection 2013
56124-62-0
XL888 was orally dosed to mice at 100 mg/kg 3 times a week in xenograft models
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
AG-120 - CAS# 1448346-63-1 164 D-A-HYDROXYGLUTARIC ACID DISODIUMAG 120 (racemic), a racemic mixture of AG 120, CAS No. 1448346 63 1, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Upon administration, AG 120 specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2 hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular
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