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Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport
InChi: InChI=1S/C28H39N7O6S/c1-18-24(42-17-31-18)20-7-5-19(6-8-20)14-30-26(38)22-13-21(36)15-35(22)27(39)25(28(2
Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer
CAS Number: 2421118-05-8
Smiles: C[C@]1(CCC[C@@]2(C)[C@H]1CC=C1C[C@](C)(CC[C@H]21)C=C)C(O)=O
OT-R antagonist 1 798rterolane Rilmenidine acts both centrally byOT R antagonist 1 is a new potent and selective nonpeptide low molecular weight OT R antagonist. OT R antagonist 1 inhibits oxytocin evoked intracellular Ca2+ mobilization (IC50 = 8 nM). IC50 value: 8 nMTarget: oxytocin receptorin vitro: OT R antagonist 1 inhibitis IP3 Synthesis, rat OT R (IC50=0. 03 uM). OT R antagonist 1 inhibits phosphodiesterase IV with IC50 = 6. 1 M, a value about 300 fold higher than the affinity for OT R. OT R antagonist 1
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