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TH-237A hexiline Maleate PubMed Central PMCID: PMC3289451

SKU: 61068329394

4.9
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Description

PubMed Central PMCID: PMC3289451

1990 Mar 15

100-fold selective for the hNK-3 versus hNK-2 receptor

Smiles: CC(C)CN1C=NC2=C(N)N=C3C=CC=CC3=C12

Solubility: DMSO : ≥ 100 mg/mL (68

TH-237A hexiline Maleate PubMed Central PMCID: PMC3289451TH 237A is a novel neuroprotective agent, which possess protective properties against amyloid (A) induced neurodegeneration associated with Alzheimer's disease. Exposure of neuronal cultures to A peptide in the presence of 5 nM TH 237A resulted in a 50% increase in survival. Neuronal cultures treated with other toxic stimuli such as staurosporine, thapsigargin, paraquat and H2O2 showed significantly enhanced survival in the presence of TH 237A .

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