SR9009 - REV-ERB Agonist. CAS# 1379686-30-2 Catalog No.:M60236-10S MLN8237 significantly inhibits cell proliferation

MLN8237 significantly inhibits cell proliferation in multiple myeloma (MM) cell lines with IC50 values of 0

HBX41108 inhibits cancer cell growth

Chemical Name: DMAT

inhibiting PARP-mediated repair of single strand DNA breaks

(2015) J Biol Chem

SR9009 - REV-ERB Agonist. CAS# 1379686-30-2 Catalog No.:M60236-10S MLN8237 significantly inhibits cell proliferationSR9009, CAS No. 1379686 30 2, is a potent and specific synthetic REV ERB agonist that binds to REV ERB with an EC50 ~670 nM and REV ERB with EC50 ~800 nM. It also has good in vivo plasma brain exposure. The nuclear receptors REV ERB and REV ERB play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9009 alters circadian behavior and the circadian pattern of core clock