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Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis
23(3):274-6
is a PEG derivative containing an azide group and an NHS ester
1627676-59-8
resulting in accumulation of polyubiquitin
OTX015 - BET Inhibitor. CAS# 202590-98-5 size:2 mg solid Glucosylceramide synthase inhibitor PDMP sensitizesOTX015, CAS No. 202590 98 5, is a novel, highly potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3 and BRD4 with IC50 of 10 19 nM. It inhibits the growth of a variety of human cancer cell lines with IC50 ranging from 60 to 200 nM. OTX015 results in rapid down regulation of c MYC expression, and show the synergistic anti proliferative effects in combination with ALK inhibitors in ALKpos