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alpha-Mangostin (α-Mangostin) selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells
InChi: InChI=1S/C22H25NO5/c1-15(22(27)28)13-19(23-20(24)11-12-21(25)26)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10
5-diamino-2-{[(2R
is a potent EGFR inhibitor with Ki and IC50 of 6 and 25 pM
OVCAR-3= 0
BML-210 Catalog No.:M12478-10 alpha-Mangostin (α-Mangostin) selectively promotes demethylationBML 210 is a novel HDAC inhibitor, and its mechanism of action has not been characterized. IC50 value: 5 M Target: HDAC4 In vitro: Cell cycle analysis indicated that HeLa cell treatment with 20 and 30 M concentration of BML 210 increased the proportion of cells in G0 G1 phase, and caused accumulation in subG1, indicating that the cells are undergoing apoptosis. BML 210 inhibits the growth of NB4 cells in dose and time dependent manner. Product