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Development of anaplastic lymphoma kinase (ALK) inhibitors and molecular diagnosis in ALK rearrangement-positive lung cancer
SM-164 imifugin Development of anaplastic lymphoma kinaseSM 164 is a potent cell permeable and bivalent Smac mimetic which bind to a XIAP protein and binds to cIAP 1 and cIAP 2 proteins. It is developed as an anticancer agent. It plays its antitumor roles through inducing degradation of cellular inhibitor of apoptosis protein (cIAP) 1 2, antagonizing X linked inhibitor of apoptosis protein (XIAP) and inducing TNFdependent apoptosis in tumor cells. SM 164 is a bivalent mimetic containing two SM 122
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