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TL12-186 is a multikinase degrading PROTAC
InChi: InChI=1S/C23H30N8O
2314467-59-7 (free base)
9bS)-9-hydroxy-6
GNE-6776 interacts with acidic residues that mediate hydrogen-bond interactions with the ubiquitin Lys48 side chain
Hypothemycin Size:2mg solid TL12-186 is a multikinase degradingHypothemycin, a fungal polyketide, is a multikinase inhibitor with Kis of 10 70 nM, 17 38 nM, 90 nM, 900 nM 1. 5 M, and 8. 4 2. 4 M for VEGFR2 VEGFR1, MEK1 MEK2, FLT 3, PDGFR PDGFR, and ERK1 ERK2, respectively. Product information CAS Number: 76958 67 3 Molecular Weight: 378. 37 Formula: C19H22O8 Chemical Name: (2R, 4R, 6S, 7S, 12S) 6, 7, 16 trihydroxy 18 methoxy 12 methyl 3, 13 dioxatricyclo[13. 4. 0. 0, ]nonadeca 1(19), 9, 15, 17 tetraene 8, 14