GNF-7 - Ras Signaling Inhibitor. CAS# 839706-07-9 60427 Interaction of canertinib with OATP1B3

Interaction of canertinib with OATP1B3 may alter its hepatic disposition and can lead to transporter mediated drug-drug interactions

CAS Number: 66428-89-5

is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC50 ~2 nM

In COLO 205 and GEO colon cancer xenograft models

Barrett SD

GNF-7 - Ras Signaling Inhibitor. CAS# 839706-07-9 60427 Interaction of canertinib with OATP1B3GNF 7, CAS No. 839706 07 9, is a potent, selective and bioavailable Ras signaling inhibitor. It inhibits Ack1 and germinal center kinase (GCK). It can suppress proliferation, and induce cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. In vivo GNF 7 showed good efficacy in a xenotransplantation model and activity against primary AML patient samples. Product information CAS Number: 839706 07 9 Molecular Weight: 547. 53