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2 nM for ERα degradation
3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H
At 100 μM Apoptosis Activator 2 exhibited 100% cytotoxicity in virtually all cell lines
InChiKey: IEPCQLHHUYRTEY-UHFFFAOYSA-N
It inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) in quantitative reporter assays of β-catenin/Tcf4 binding (Ki = 53
Cobimetinib (R) - CAS# 934660-94-3 0305 2 nM for ERα degradationCobimetinib (R) is the less active R enantiomer of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor. Product information CAS Number: 934660 94 3 Molecular Weight: 531. 31 Formula: C21H21F3IN3O2 Synonym: GDC 0973 R enantiomer XL 518 R enantiomer Chemical Name: 1 {3,4 difluoro 2 [(2 fluoro 4 iodophenyl)amino]benzoyl} 3 [(2R) piperidin 2 yl]azetidin 3 ol Smiles: OC1(CN(C1)C(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F)[C@H]1CCCCN1 InChiKey: