CDK12-IN-4 bic acid 2-phosphate radotinib specifically inhibits the Bcr-Abl

radotinib specifically inhibits the Bcr-Abl fusion protein

Formula: C16H15BrClN5O4S

and the subsequent increase in the production of vascular endothelial NO

Formula: C18H19N7O2

and a rash

CDK12-IN-4 bic acid 2-phosphate radotinib specifically inhibits the Bcr-AblCDK12 IN 4, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 0. 641 M at high ATP (2 mM). CDK12 IN 4 has no effect on CDK2 Cyclin E (IC50>20 M) and CDK9 Cyclin T1 (IC50>20 M) at high ATP (2 mM) (WO2021116178A1). Product information CAS Number: 2651196 69 7 Molecular Weight: 426. 42 Formula: C20H20F2N8O Chemical Name: 8 cyclopropyl N ((6, 7 difluoro 1H benzo[d]imidazol 2 yl)methyl) 2 morpholinopyrazolo[1, 5 a][1, 3, 5]triazin 4 amine