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3)12(10)17)11(16)14(4
2-oxazol-4-yl)(hydroxy)methyl]-1-benzofuran-5-yl}-N-[(S)-(2
Kucerova L
InChiKey: ALIVXCSEERJYHU-UHFFFAOYSA-N
and addiction
PCS1055 dihydrochloride Catalog No.:M32998-C 3)12(10)17)11(16)14(4PCS1055 dihydrochloride is a potent, selective and competitive muscarinic M4 receptor antagonist with an IC50 of 18. 1 nM and a Kd of 5. 72 nM. PCS1055 dihydrochloride inhibits radioligand [3H] NMS binding to the M4 receptor with a Ki of 6. 5 nM. PCS1055 dihydrochloride exhibits >100 fold selectivity over M1 , M3 , and M5 receptors and 30 fold selectivity at the M2 receptor. PCS1055 dihydrochloride is also a potent AChE inhibitor with IC50 s of 22 nM
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