(±)-AMG 487 CS-010759 InChi: InChI=1S/C76H154N2O38/c1-80-4-5-82-8-9-84-12-13-86-16-17-88-20-21-90-24-25-92-28-29-94-32-33-96-36-37-98-40-41-100-44-45-102-48-49-104-52-53-106-56-57-108-60-61-110-64-65-112-68-69-114-72-73-116-75-74-115-71-70-113-67-66-111-63-62-109-59-58-107-55-54-105-51-50-103-47-46-101-43-42-99-39-38-97-35-34-95-31-30-93-27-26-91-23-22-89-19-18-87-15-14-85-11-10-83-7-6-81-3-2-76(79)78-77/h2-75

Name: (±)-AMG 487 CS-010759 InChi: InChI=1S/C76H154N2O38/c1-80-4-5-82-8-9-84-12-13-86-16-17-88-20-21-90-24-25-92-28-29-94-32-33-96-36-37-98-40-41-100-44-45-102-48-49-104-52-53-106-56-57-108-60-61-110-64-65-112-68-69-114-72-73-116-75-74-115-71-70-113-67-66-111-63-62-109-59-58-107-55-54-105-51-50-103-47-46-101-43-42-99-39-38-97-35-34-95-31-30-93-27-26-91-23-22-89-19-18-87-15-14-85-11-10-83-7-6-81-3-2-76(79)78-77/h2-75
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Description

InChi: InChI=1S/C76H154N2O38/c1-80-4-5-82-8-9-84-12-13-86-16-17-88-20-21-90-24-25-92-28-29-94-32-33-96-36-37-98-40-41-100-44-45-102-48-49-104-52-53-106-56-57-108-60-61-110-64-65-112-68-69-114-72-73-116-75-74-115-71-70-113-67-66-111-63-62-109-59-58-107-55-54-105-51-50-103-47-46-101-43-42-99-39-38-97-35-34-95-31-30-93-27-26-91-23-22-89-19-18-87-15-14-85-11-10-83-7-6-81-3-2-76(79)78-77/h2-75

3-NT and MDA production

ITX3 is a nontoxic selective cell active inhibitor of the Trio/RhoG/Rac1 pathway

16-7+/t17-

PubMed PMID: 26392512

(±)-AMG 487 CS-010759 InChi: InChI=1S/C76H154N2O38/c1-80-4-5-82-8-9-84-12-13-86-16-17-88-20-21-90-24-25-92-28-29-94-32-33-96-36-37-98-40-41-100-44-45-102-48-49-104-52-53-106-56-57-108-60-61-110-64-65-112-68-69-114-72-73-116-75-74-115-71-70-113-67-66-111-63-62-109-59-58-107-55-54-105-51-50-103-47-46-101-43-42-99-39-38-97-35-34-95-31-30-93-27-26-91-23-22-89-19-18-87-15-14-85-11-10-83-7-6-81-3-2-76(79)78-77/h2-75() AMG 487 is a racemate of AMG 487. AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8. 0 and 8. 2 nM, respectively. Product information CAS Number: 947536 03 0 Molecular Weight: 603. 59 Formula: C32H28F3N5O4 Chemical Name: N {1 [3 (4 ethoxyphenyl) 4 oxo 3H,4H pyrido[2,3 d]pyrimidin 2 yl]ethyl} N [(pyridin 3 yl)methyl] 2 [4

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