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Lawrence AJ
PubMed PMID: 26738988
Epub 2014 Feb 4
2-b]carbazole-6-carbaldehyde
High affinity proteasome inhibitor (Ki = 0
CZC-54252 443 Lawrence AJCZC 54252 is a potent inhibitor of leucine rich repeat kinase 2 (LRRK2) with IC50 values 1. 28 nM and 1. 85 nM for wild type and G2019S mutant forms of LRRK2 respectively. CZC 54252 attenuates neuronal injury induced by LRRK2 G2019S mutant activity in primary human neurons (EC50 = 1 nM). Activating mutations in leucine rich repeat kinase 2 (LRRK2) are present in a subset of Parkinson's disease (PD) patients and may represent an attractive therapeutic
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