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especially the alpha-1 subunit
Formula: C15H14O5
Doxorubicin is released from the albumin carrier after cleavage of the acid-sensitive hydrazone linker within the acidic environment of tumors and
Formula: C20H19ClN6O2
but also patient-derived tumor cells
Bafetinib analog, Lyn-IN-1 - CAS# 887650-05-7 clozanide especially the alpha-1 subunitBafetinib, also known as INNO 406 and NS187, is an orally bioavailable 2 phenylaminopyrimidine derivative with potential antineoplastic activity. Bafetinib specifically binds to and inhibits the Bcr Abl fusion protein tyrosine kinase, an abnormal enzyme produced by Philadelphia chromosomal translocation associated with chronic myeloid leukemia (CML). This agent also inhibits the Src family member Lyn tyrosine kinase, upregulated in imatinib resistant
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