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or dexamethasone triggered synergistic anti-MM activity
The inhibition of growth of human tumor xenografts in mice
and has slight activity against HDAC8 (IC50 ~0
PubMed PMID: 24434211
10 and 30 mg/kg) significantly reduces ethanol intake relative to vehicle and does not effect water consumption in female P rats
SC-26196 - CAS# 218136-59-5 0060 or dexamethasone triggered synergistic anti-MMSC 26196, CAS No. 218136 59 5, is a D6D inhibitor (IC50 = 0. 2 M in a rat liver microsomal assay) that completely blocks the conversion of linoleic acid to arachidonic acid (AA). SC 26196 inhibited the desaturation of 2 microM [1 14C] 18: 2n 6 by 87 95% in cultured human skin fibroblasts, coronary artery smooth muscle cells, and astrocytes. By contrast, SC 26196 did not affect the conversion of [1 14C]20: 3n 6 to 20: 4 in the fibroblasts,