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EX-527 - SIRT1 Inhibitor. CAS# 49843-98-3 60071 LY2784544 significantly inhibits STAT5 phosphorylation

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Description

LY2784544 significantly inhibits STAT5 phosphorylation in JAK2-V617F Ba/F3 xenografts

3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes

Cell Mol Biol Lett

InChiKey: QFJCIRLUMZQUOT-BLBZBZKNSA-N

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

EX-527 - SIRT1 Inhibitor. CAS# 49843-98-3 60071 LY2784544 significantly inhibits STAT5 phosphorylationEX 527, CAS No. 49843 98 3, is a highly potent and selective inhibitor of SIRT1 with an IC50 ~98 nM. It does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 ~20 100 M). EX 527 has been used to investigate the relationship between SIRT1 mediated deacetylation of p53, p53 activity, and cell survival following DNA damage, as well as many other biological processes involving SIRT1. Product information CAS Number:

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