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Formula: C11H14ClNO3
Napabucasin inhibits PaCa-2 xenograft tumor growth in mice
and this effect was shown to be associated with reorganisation of ZO-1 to the cell periphery in Con8 mammary epithelial tumor cells
42(5):1822-1836
Kalthoff F
ATP (disodium salt) quantel Formula: C11H14ClNO3RO4987655, also known as CH4987655, is an orally active small molecule, targeting mitogen activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK inhibitor RO4987655 binds to and inhibits MEK, which may result in the inhibition of MEK dependent cell signaling and the inhibition of tumor cell proliferation. MEK, a dual specificity threonine tyrosine kinase, is a key component of the RAS RAF MEK ERK signaling
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