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Effects of 22-oxa-calcitriol on podocyte injury in adriamycin-induced nephrosis
3(5):568-74
Chemical Name: 4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1
07 µM and ~0
with IC50 values of 79 μM and 2
COTI-2 nositol Effects of 22-oxa-calcitriol on podocyteCOTI 2, an anti cancer drug with low toxicity, is an orally available third generation activator of p53 mutant forms. COTI 2 acts both by reactivating mutant p53 and inhibiting the PI3K AKT mTOR pathway. COTI 2 induces apoptosis in multiple human tumor cell lines. COTI 2 exhibits antitumor activity in HNSCC through p53 dependent and independent mechanisms. COTI 2 converts mutant p53 to wild type conformation. Product information CAS Number: 1039455 84
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