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InChi: InChI=1S/C25H21N5O
8E)-9-(3-hydroxy-2
Koumine induces apoptosis
an inverse agonist at 5-HT7 (IC50=150 nM)
CAS Number: 614-47-1
EGFR-IN-11 Size:Contact [email protected] for quotation InChi: InChI=1S/C25H21N5OEGFR IN 11 is a fourth generation EGFR tyrosine kinase inhibitor (EGFR TKI) with an IC50 of 18 nM for triple mutant EGFRL858R T790M C797S. EGFR IN 11 significantly suppresses the EGFR phosphorylation, induce the apoptosis, and arrest cell cycle at G0 G1. Product information CAS Number: 2463200 44 2 Molecular Weight: 573. 71 Formula: C29H35N9O2S Chemical Name: 9 [(3R) 1 (cyclopropanesulfonyl)pyrrolidin 3 yl] N2 [4 (4 methylpiperazin 1 yl)phenyl] N8
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