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Intraperitoneal injections of AS1517499 (10 mg/kg) 1 hour before each ovalbumin exposure inhibits both the antigen-induced up-regulation of RhoA and BSM hyperresponsiveness
9 μM respectively
A study on the ocular and extraocular pharmacology of metipranolol
8 µM to 3
potentiates a wide range of cytotoxics and even to offer some protection of normal cells
GQ-16 lator 1 Intraperitoneal injections of AS1517499 (10GQ 16 is a novel partial agonist of peroxisome proliferator activated receptor (PPAR) involved in promoting insulin sensitization . PPAR is mainly involved in fat cell differentiation and insulin sensitivity. In vitro: GQ 16 was an effective inhibitor of Cdk5 mediated phosphorylation of PPAR, exhibiting a Ki value of 160 nM. GQ 16 was specific for PPAR and possessed no detectable activity when tested for the ability to activate other PPAR subtypes