ZJ 43 60075 21dF and 21dE are in

21dF and 21dE are in fact metabolised to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1

Formula: C25H30F3N3O2

3 hours) has anti-inflammatory activity by attenuating the UVB-induced IL-6 synthesis in HaCaT cells

ML-193 (5 μM

but shows no significant effect on IgG and C3 deposition in NZB/W mice

ZJ 43 60075 21dF and 21dE are inIC50: 2. 4 nM ZJ 43 is a N acetylaspartylglutamate (NAAG) peptidase inhibitor. The peptide neurotransmitter N acetylaspartylglutamate (NAAG) is reported to act as an agonist at group II metabotropic glutamate receptors. NAAG is inactivated by extracellular peptidase activity leading to yielding glutamate and N acetylaspartate. In vitro: As a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III) with Kivalues of 0. 8 and 23 nM