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InChi: InChI=1S/C29H34FNO2/c1-7-11-24-27(26(20(6)32)29(19(4)5)31-28(24)18(2)3)23-15-14-22(30)16-25(23)33-17-21-12-9-8-10-13-21/h7-16
InChiKey: GCFBRXLSHGKWDP-XCGNWRKASA-N
ClH/c1-13-16-11-14(21)3-6-19(16)28-20(13)29(25
with IC50 and KD values close to or below 1 nM as well as a slow dissociation rate
KN-62 is a selective antagonist of Ca2+/calmodulin-dependent protein kinase II (CaMKII)
Sorafenib Tosylate - CAS# 475207-59-1 rizine dihydrochloride InChi: InChI=1S/C29H34FNO2/c1-7-11-24-27(26(20(6)32)29(19(4)5)31-28(24)18(2)3)23-15-14-22(30)16-25(23)33-17-21-12-9-8-10-13-21/h7-16Sorafenib, also known as BAY 43 9006, is a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF MEK ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR 2 PDGFR beta signaling cascade, thereby blocking tumor angiogenesis. Sorafenib was approved in 2005 for use in the treatment of advanced renal cancer. Product
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