PYR-41 - Ubiquitin-activating Enzyme E1 Inhibitor. CAS# 418805-02-4 Catalog No.:M60201-10S injections of 40 mg/kg/day canertinib

injections of 40 mg/kg/day canertinib (Fig

LY294002 could be dosed to the mice by IP administration at 100 mg/kg once day

000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases

Chemical Name: (S)-2-((2R

but not mTORC2

PYR-41 - Ubiquitin-activating Enzyme E1 Inhibitor. CAS# 418805-02-4 Catalog No.:M60201-10S injections of 40 mg/kg/day canertinibPYR 41, CAS No. 418805 02 4, is a ubiquitin activating enzyme inhibitor (UBE1 inhibitor). PYR 41 blocks ubiquitination reactions but paradoxically leads to the accumulation of high MW ubiquitinated proteins. PYR 41 also mediated cross linking of specific protein kinases (Bcr Abl, Jak2) to inhibit their signaling activity. PYR 41 has demonstrated anti tumor activity in animal studies, partially selective protein cross linking may represent an alternate