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Insensitivity to Pain upon Adult-Onset Deletion of Nav1
PubMed Central PMCID: PMC4490757
CAS Number: 348086-71-5
13-dimethyl-2
InChi: InChI=1S/C154H244N48O29/c1-18-87(11)121-141(226)190-108(73-84(5)6)131(216)188-112(78-118(206)207)136(221)199-153(16
Biperiden ader-3 Insensitivity to Pain upon Adult-OnsetAZD8186 is and inhibitor of the beta isoform of phosphoinositide 3 kinase (PI3K), with potential antineoplastic activity. Upon administration, PI3Kbeta inhibitor AZD8186 selectively inhibits the activity of PI3Kbeta in the PI3K Akt mTOR signaling pathway, which may result in a decrease of tumor cell proliferation. It also induces cell death in PI3K expressing cancer cells. By specifically targeting class I PI3K beta, this agent may be more efficacious