ONO-4059 (analog) or modulator-1 A novel PI3K inhibitor alleviates

A novel PI3K inhibitor alleviates fibrotic responses in fibroblasts derived from Peyronie's plaques

highly selective for vascular

but does not affect an established asthmatic attack

FDA approved this drug for for actinic keratosis

ISO-1 has CAS#478336-92-4

ONO-4059 (analog) or modulator-1 A novel PI3K inhibitor alleviatesONO 4059 analog is the analog of ONO 4059, ONO 4059 is a highly potent and selective Btk inhibitor. IC50 value: sub nM range Target: Btkin vitro: ONO 4059 is a selective, once daily, oral inhibitor of BTK, which has been shown to play a role in the survival and proliferation of malignant B cells. ONO 4059 shows a favourable safety profile along with promising efficacy in this difficult to treat patient population. in vivo: ONO 4059 has demonstrated