Ponesimod bersonine hydrochloride is a signal transducer and

is a signal transducer and activator of transcription 3 (STAT3) inhibitor against human head and neck squamous cell carcinoma (HNSCC)

with a Kd of 79 nM

Smiles: CC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@]1(C)CCCC=CCCC[C@](C)(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |c:83|

71(6):1049-51

Chemical Name: 5-[(2-{4-[1-(2-hydroxyethyl)piperidin-4-yl]benzamido}pyridin-4-yl)oxy]-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide

Ponesimod bersonine hydrochloride is a signal transducer andPonesimod (ACT 128800) is a potent, selective and orally active agonist of S1P1, with an IC50 of 6 nM in a radioligand binding assay. Ponesimod activates S1P1 mediated signal transduction with high potency (EC50=5. 7 nM). Ponesimod can protect against lymphocyte mediated tissue inflammation. Product information CAS Number: 854107 55 4 Molecular Weight: 460. 97 Formula: C23H25ClN2O4S Chemical Name: (2E,5Z) 5 ({3 chloro 4 [(2S) 2,3