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The prosurvival BCL-2 family protein BCL-X(L) is often overexpressed in solid tumors and renders malignant tumor cells resistant to anticancer therapeutics
Formula: C14H17IN4O2
It blocks LPS-induced expression of inflammatory cytokines in human myelomonocytic cells
Chemical Name: 4-amino-N-(1
000-fold selectivity over a large panel of human kinases
Miltefosine - CAS# 58066-85-6 halomannine The prosurvival BCL-2 family proteinMiltefosine is an orally and topically active alkyl phosphocholine compound with potential antineoplastic activity. Miltefosine targets cellular membranes, modulating cell membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti apoptotic mitogen activated protein kinase (MAPK) pathway and modulates
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