Chlorcyclizine (hydrochloride) Catalog No.:M22827-C C1[C@@H](N=C2SCCN21)C1C=CC=CC=1

C1[C@@H](N=C2SCCN21)C1C=CC=CC=1

Lepeleire I

InChi: InChI=1S/C11H18N2O5S/c1-2-5-19-6-8(11(17)18)13-9(14)4-3-7(12)10(15)16/h2

PubMed Central PMCID: PMC4003123

Smiles: C[C@@H](O)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H](CC1C=CC(O)=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CS)C(=O)NCC(=O)N[C@@H](CS)C(O)=O

Chlorcyclizine (hydrochloride) Catalog No.:M22827-C C1[C@@H](N=C2SCCN21)C1C=CC=CC=1Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor . The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking. Histamine has been involved in circadian rhythm of locomotor activity and exploratory behavior through H1R . In vitro: The Ki value of chlorcyclizine for histamine H1 receptor was 9 nM . Chlorcyclizin was effective