Ki-16425 - CAS# 355025-24-0 pound Library of Histone Demethylase NI-57 was used at 10

NI-57 was used at 10 µM final concentration in vitro and in cellular assays

is the first selective and potent inhibitor of the H3K27 histone demethylases UTX and JMJD3

to BRPF2 with a KD of 108 nM (ITC) and to BRPF3 KD of 408 nM (ITC)

DU145 and COLO 205

It causes cell death through the apoptosis pathway

Ki-16425 - CAS# 355025-24-0 pound Library of Histone Demethylase NI-57 was used at 10Ki16425, CAS No. 355025 24 0, is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0. 34 M, 6. 5 M and 0. 93 M, respectively, shows no activity at LPA4, LPA5, LPA6. IC50 value: 0. 3 6. 5 0. 93 uM(Ki, LPA1 2 3) Target: LPA1 2 3 Product information CAS Number: 355025 24 0 Molecular Weight: 474. 96 Formula: C23H23ClN2O5S Chemical Name: 3 ((4 (4 (((1 (2 chlorophenyl)ethoxy)carbonyl)amino) 3 methylisoxazol 5