D-α-Hydroxyglutaric acid odesine 2018 Jun 10

2018 Jun 10

6-bis(propan-2-yl)pyridin-3-yl]-3

with an apparent Ki of 10 μM

which is a third-generation EGFR inhibitor

Smiles: CC1C=C(C(=CC=1)N1N=CC=N1)C(=O)N1CCN(CC[C@H]1C)C1=NC2=CC(Cl)=CC=C2O1

D-α-Hydroxyglutaric acid odesine 2018 Jun 10D Hydroxyglutaric acid ((R) 2 Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D 2 hydroxyglutaric aciduria. D Hydroxyglutaric acid is a weak competitive antagonist of ketoglutarate ( KG) and inhibits multiple KG dependent dioxygenases with a Ki of 10. 87 mM. D Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling.