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Chemical Name: N-{[(5S)-3-[2-fluoro-4'-({[(2H-1
6R)-2-(6-chloropyridin-3-yl)-1
including gram-positive and gram-negative bacteria
57-40)55-17-15-27(54-10)22(4)39(56-26(8)47)24(6)36(49)23(5)35(48)20(2)12-11-13-21(3)42(53)45-33(34(32)46)38(30)51/h11-18
4)33)26-13-14-27-23(10-7-16-30(26
A-366 044SB069 Chemical Name: N-{[(5S)-3-[2-fluoro-4'-({[(2H-1A 366 is a potent, highly selective, peptide competitive histone methyltransferase G9a inhibitor with IC50s of 3. 3 and 38 nM for G9a and GLP (EHMT1), respectively. A 366 shows >1000 fold selectivity over 21 other methyltransferases. A 366 is also a potent, nanomolar inhibitor of the Spindlin1 H3K4me3 interaction (IC50=182. 6 nM). A 366 displays high affinity at human histamine H3 receptor (Ki=17 nM) and shows subtype selectivity among subsets of the
US$ 4630.00
US$ 1329.00