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D-A-HYDROXYGLUTARIC ACID DISODIUM
CW-069 (100 or 200 μM) causes increased multipolar spindles in N1E-115 cells with supernumerary centrosomes and shows no effect on altering bipolar spindle morphology in normal human dermal fibroblast cells
is a potent proteasome inhibitor (PI) with potential antineoplastic activity
with IC50s of 18
engraftment and early tumor growth are significantly decreased
Kenpaullone - CAS# 142273-20-9 60204 D-A-HYDROXYGLUTARIC ACID DISODIUMKenpaullone, CAS No. 142273 20 9, is a potent inhibitor of CDK1 cyclin B (IC50 = 400 nM), CDK2 cyclin A (IC50 = 680 nM), CDK2 cyclin E (IC50 = 7. 5 uM) and CDK5 p25 (IC50 = 850 nM). Kenpaullone inhibits CDK2 cyclin A, CDK2 cyclin E and CDK5 cyclin p35 (IC50 values are 0. 68, 7. 5 and 0. 85 M respectively). Product information CAS Number: 142273 20 9 Molecular Weight: 327. 18 Formula: C16H11BrN2O Synonym: NSC664704 NSC 664704 Kenpaullone NSC 664704
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