Anle138b 57-9352) with a Ki of 1

with a Ki of 1 μM

The EC50 value

Formula: C23H30N6O4

Vincasar PFS

Part 3: preparation of 2'-N-acyl derivatives of ecteinascidin 770 and evaluation of cytotoxicity

Anle138b 57-9352) with a Ki of 1Anle138b, an oligomeric aggregation inhibitor, blocks the formation of pathological aggregates of prion protein (PrPSc) and of synuclein ( syn). Anle138b strongly inhibits oligomer accumulation, neuronal degeneration, and disease progression in vivo. Anle138b has low toxicity and an excellent oral bioavailability and blood brain barrier penetration. Anle138b blocks A channels and rescues disease phenotypes in a mouse model for amyloid pathology.