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selective and cell permeable type I PRMT inhibitor (catalyzes mono- and asymmetric dimethylation of arginine residues) with IC50 of 30 nM
with an EC50 value of 17
CAS Number: 882157-88-2
Formula: C11H8O2
selective and reversible fatty acid amide hydrolase (FAAH) inhibitor
AG-636 217903 selective and cell permeable typeAG 636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. Differential AG 636 activity translated to the in vivo setting, with complete tumor regression observed in a lymphoma model. Dissection of the relationship between uridine availability and response to AG 636 revealed a divergent ability of lymphoma and solid tumor cell lines to survive and grow in the setting of depleted