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LY2157299 - TGFβ Inhibitor. CAS# 700874-72-2 size:10mg solid 708219-39-0

SKU: 21780543176

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Description

708219-39-0

PubMed Central PMCID: PMC2976054

Schultz GS

a PDGFR inhibitor

ATP-competitive inhibitor of Akt

LY2157299 - TGFβ Inhibitor. CAS# 700874-72-2 size:10mg solid 708219-39-0LY2157299, CAS No. 700874 72 2, is a novel potent and selective TGF receptor type I and type II (TRI II) inhibitor with IC50 of 86 nM and 2 nM, respectively. LY2157299 could inhibit the TGF induced Smad2 phosphorylation in HUVEC cells, promote VEGF induced HUVEC cell migration, and show dose dependent potentiation of VEGF or bFGF induced cell proliferation. It can also inhibit TGFmediated Smad2 activation and hematopoietic suppression in primary

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