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24(12):3133-3145
⁷]dodeca-1(9)
7-naphthyridin-4-yl)phenyl]methyl}piperazin-1-yl)pentyl]oxy}-4-(4-methyl-1
and antiprotozoal properties
irreversible inhibitor of the enzyme ornithine decarboxylase
CEP 1347 ITC 24(12):3133-3145CEP 1347, also called KT 7515, is an inhibitor of the c Jun N terminal kinase (JNK) signaling pathway, with an IC50 value for JNK1 activation of 20 2 nM in rat embryonic motoneurons . The JNK pathway, also known as the stress activated protein kinase (SAPK) pathway, is one of the signaling cascades that mediate the apoptotic death in response to a variety of stressful stimuli. JNK activation by phosphorylation is important for neuronal cell death
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