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2016 Mar 1
Linnanto JM
EPZ015666 represents a validated chemical probe for further study of PRMT5 biology and arginine methylation in cancer and other diseases
Chemical Name: 2-[(5Z)-5-({4-[4-(2
It potently inhibits G9a/GLP methyltransferase activity in cells (IC50 ~10 nM in MCF7 cells)
Tenovin-6 - CAS# 1011557-82-6 cetrapib 2016 Mar 1Tenovin 6, also known as Tnv 6, is a bioactive small molecule SIRT2 inhibitor with anti neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro apoptotic effects of Tnv 6 in many tumors. Tnv 6 causes non genotoxic cytotoxicity, without adversely affecting human clonogenic hematopoietic progenitors in vitro, or murine hematopoiesis. Mechanistically, exposure of CLL cells to
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