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Smiles: NC1=NC(SCC2=CSC(=N2)C2=CC=C(Cl)C=C2)=C(C#N)C(=C1C#N)C1C=CC(=CC=1)OCCO
Gutierrez-Cuesta J
subtype specific analogue for adenosine
InChi: InChI=1S/C27H43NO2/c1-16-7-12-27(28-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(29)8-10-25(18
is a potent and selective
Vidofludimus nolone (acetonide) Smiles: NC1=NC(SCC2=CSC(=N2)C2=CC=C(Cl)C=C2)=C(C#N)C(=C1C#N)C1C=CC(=CC=1)OCCOVidofludimus, also known as 4SC 101 or SC12267, is a novel orally active and potent DHODH inhibitor. In vitro, 4SC 101 is a potent inhibitor of human DHODH, inhibits lymphocyte proliferation, and uniquely blocks phytohemagglutinin stimulated IL 17 production by lymphocytes. In vivo, oral administration of 4SC 101 effectively improved both chronic DSS and acute TNBS colitis in mice. 4SC 101 may have potential for the treatment of intestinal