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For instance, if your opponent is bursting at the seams with token creatures, you might mill yourself out by drawing an equal amount of cards

With the exception of Glorious End, ending your opponents turn costs six mana at the least

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The mana value of a spell cast using More Than Meets the Eye is determined by the mana cost on the front face of the card, no matter what the total cost to cast the spell was

Conclusion I think that most Commander decks will benefit from playing a board wipe or two, because you simply cant guarantee that the natural variance of the format will always be in your favor