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Epub 2013 Sep 27
Huiliang Song
CAS Number: 1207989-09-0
InChi: InChI=1S/C25H28O6/c1-13(2)5-6-15(14(3)4)9-18-20(28)11-21(29)24-22(30)12-23(31-25(18)24)17-8-7-16(26)10-19(17)27/h5
Formula: C96H120N12Na6O21
O-1602 Catalog No.:M22717-C Epub 2013 Sep 27O 1602 is an agonist of GPR55 (EC50 = 13 nM in a GTPS binding assay) and a derivative of the GPR55 agonist abnormal cannabidiol. It is selective for GPR55 over cannabinoid (CB) receptor 1 (CB1) and CB2 (EC50s = >30 M for both in GTPS binding assays). O 1602 (50 M) reduces growth of Mz ChA 1, HuCCT 1, CC LP 1, and SG231 cholangiocarcinoma cells and reduces tumor growth in a Mz ChA 1 mouse xenograft model when administered at a dose of 10 mg kg per day.
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