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thereby reducing secretion of luteinizing hormone (LH) by pituitary gonadotroph cells and so decreasing testosterone production by interstitial (Leydig) cells in the testes
InChiKey: SRQKTCXJCCHINN-NYYWCZLTSA-N
InChi: InChI=1S/C55H70N6O9/c1-38(60(2)55(66)70-37-46-44-25-14-12-23-42(44)43-24-13-15-26-45(43)46)51(62)58-49(41-21-10-5-11-22-41)54(65)61-30-16-27-47(61)52(63)59-50(48(39-17-6-3-7-18-39)40-19-8-4-9-20-40)53(64)57-29-32-68-34-36-69-35-33-67-31-28-56/h3-4
InChi: InChI=1S/C25H17F3N4O3/c26-25(27
CAS Number: 25739-41-7
TCS 2002 iclopirox thereby reducing secretion of luteinizingTCS 2002 is a potent inhibitor of GSK 3 with IC50 value of 35 nM . Glycogen synthase kinase 3 (GSK 3) is a serine threonine protein kinase and functions by phosphorylating a serine or threonine residue on its target protein. GSK3 plays an important role in neuronal cell development, energy metabolism and body pattern formation. TCS 2002 is a potent GSK 3 inhibitor with IC50 value of 35 nM. (S) TCS 2002 and (R) TCS 2002 inhibited GSK 3 with IC50 values
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