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PubMed PMID: 22396724
GNF-7 was used at 1 µM final concentration in vitro and in cellular assays
InChiKey: XQQYORJJFZQWNA-UHFFFAOYSA-N
3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2
6-dichlorophenyl)-1-[(1S
DDMS - CAS# 206052-03-1 )-87 PubMed PMID: 22396724DDMS is a CYP4A2 enzyme inhibitor. Biosynthesis of 20 HETE from arachidonic acid by the cytochrome P450 4A (CYP450 4A) isoforms is a key component of vascular homeostasis, especially in renal circulation. In vitro: To determine whether inhibition of 20 HETE contributes to the vasodilatory effects of NO, the effects of DDMS on the response to SNP were examined in rat renal arterioles preconstricted with phenylephrine). Results showed that after DDMS
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