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Smiles: CC(=O)NC1=NC2C(=CC=CC=2S1)OC1=CC(=NC=N1)C1C=CC(=CC=1)C(F)(F)F
Formula: C35H46FN5O9S
Formula: C47H57ClFN7O8S
Formula: C29H31F3N6O2
Regorafenib monohydrate is a multi-target inhibitor for VEGFR1/2/3
NVP-TAE 226 - CAS# 761437-28-9 hlorobenzyl)-N2 N2-dimethyl-N1-(pyridin-2-yl)ethane-1 2-diamine hydrochloride Smiles: CC(=O)NC1=NC2C(=CC=CC=2S1)OC1=CC(=NC=N1)C1C=CC(=CC=1)C(F)(F)FTAE226 is a novel and potent ATP competitive inhibitor of FAK and IGF IR with potential anticancer activity. TAE226 can block FAK and IGF IR signaling pathways. TAE226 inhibited the phosphorylation of FAK as well as the downstream effectors AKT, extracellular signal related kinase, and S6 ribosomal protein in multiple glioma cell lines. TAE226 induced a concentration dependent decrease in cellular proliferation with an associated G(2) cell cycle
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