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(Z)-4-Hydroxytamoxifen - CRISPR Editing Enhancer. CAS# 68047-06-3 0124 Takizawa T

SKU: 10101666873

4.4
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Description

Takizawa T

is a c-Myc/Max interaction inhibitor

PubMed PMID: 22713795

Huehnchen P

significant effects against a mouse fibroblast transfected with human EGFR

(Z)-4-Hydroxytamoxifen - CRISPR Editing Enhancer. CAS# 68047-06-3 0124 Takizawa T(Z) 4 Hydroxytamoxifen (also called 4 OH TAM), CAS No. 68047 06 3, was previously characterized as an Estrogen Receptor antagonist and now found to improve genome editing specificity in CRISPR mediated gene editing. It can activate intein linked inactive Cas9, reducing off target. Such system has ~25 fold higher specificity than wtCas9. (Z) 4 Hydroxytamoxifen is a Tamoxifen metabolite to be used as chemotherapeutic agent. It exhibits greater potency

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