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Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders
7 nM (human)
R428 inhibits Axl with low nanomolar activity and blocked Axl-dependent events
SMND-309 promotes neuron survival through the activation of the PI3K/Akt/CREB-signalling pathway
InChiKey: CZZFYGAXGATDNG-UHFFFAOYSA-N
Damnacanthal Size:Contact [email protected] for quotation Identification of a selective andDamnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 lck autophosphorylation and phosphorylation of exogenous substrates with IC50s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti inflammatory effects in
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