(R)-(+)-Etomoxir Sodium Salt rtine Maleate 0000000000000364

0000000000000364

HTH-01-015 will serve as useful chemical probes to delineate the biological roles of the NUAK kinases

triggering rapid accumulation of polyubiquitinated proteins

and breast tumor cell lines expressing mutant KRAS or wild-type or mutant BRAF

PubMed Central PMCID: PMC4471626

(R)-(+)-Etomoxir Sodium Salt rtine Maleate 0000000000000364Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1 (CPT 1) on the outer face of the inner mitochondrial membrane. This prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria. This step is essential to the production of ATP from fatty acid oxidation. Etomoxir has also been identified as a direct agonist of PPAR.