Setipiprant 8129 13-tetraoxa-1-azapentadecan-1-yl)-2-(2

13-tetraoxa-1-azapentadecan-1-yl)-2-(2

1714146-59-4

3)34-21(31)18-28-12-10-27-11-13-29(19-22(32)35-25(4

Van Glabbeke M

Solubility: H2O : 50 mg/mL (494

Setipiprant 8129 13-tetraoxa-1-azapentadecan-1-yl)-2-(2Setipiprant is an orally available, selective CRTH2 antagonist. CRTH2 is a G protein coupled receptor for PGD2. IC50 value: 6. 0 nMTarget: PGD2in vitro: Setipiprant is an orally available, selective CRTH2 (chemoattractant receptor homologous molecule expressed on T helper [Th] 2 cells) antagonist. CRTH2 is a G protein coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases,