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SSR128129E - CAS# 848318-25-2 272 Paulsen JE

SKU: 81023191677

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Description

Paulsen JE

PubMed PMID: 27889758

In the human CLL NSG xenograft model

Neuville S

Pickering DS

SSR128129E - CAS# 848318-25-2 272 Paulsen JESSR128129E (SSR), CAS No. 848318 25 2, is an potent FGFR inhibitor, which inhibits fibroblast growth factor receptor (FGFR) signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding. SSR128129E exhibits allosteric properties, including probe dependence, signaling bias, and ceiling effects. Inhibition by SSR128129E is highly conserved throughout the animal kingdom. Oral delivery of SSR128129E inhibits arthritis and

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