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It covalently binds to the cysteine 88 of ubiquitin receptor RPN13 in the 19S regulatory particle and inhibits proteasome function
PubMed PMID: 26970577
whereas zolpidem showed a more sustained WASO effect
Epub 2012 Mar 1
Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning
Afuresertib HCl - CAS# 1047645-82-8 Catalog No.:M6857-2 It covalently binds to theAfuresertib HCl, CAS No. 1047645 82 8, also known as GSK2110183, is an orally bioavailable inhibitor of the serine threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2110183 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K Akt signaling pathway is